https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52044 Wed 27 Sep 2023 10:07:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45264 Wed 26 Oct 2022 18:09:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45194 n = 294, 95–106 years; controls: n = 1105, 55–65 years) by assessing their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of p < 5 x 10⁻⁵. PRS were constructed using GWAS summary data from two exceptional longevity (EL) analyses and eight cardiovascular-related risk factors (lipids) and disease (myocardial infarction, coronary artery disease, stroke) analyses. A higher genetic risk for exceptional longevity (EL) was significantly associated with longevity in our sample (odds ratio (OR) = 1.19–1.20, p = 0.00804 and 0.00758, respectively). Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing. In conclusion, ELL individuals did not have significantly lower polygenic risk for the majority of the investigated cardiovascular health traits. Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL.]]> Wed 26 Oct 2022 14:27:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47731 g| ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.]]> Wed 25 Jan 2023 14:39:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37320 Wed 24 Nov 2021 15:51:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30085 Wed 24 Nov 2021 15:50:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44073 Wed 22 Mar 2023 15:46:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30882 Wed 17 Nov 2021 16:28:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24759 -11). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health.]]> Wed 15 Dec 2021 16:09:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37079 Wed 15 Dec 2021 16:07:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47126 Wed 14 Dec 2022 14:45:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47107 Wed 14 Dec 2022 14:23:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47086 0.05). Similar results were found for IBS subtypes. Higher serum L-arginine concentration had the strongest association with IBS diagnosis, with an odds ratio of 9.03 for those with serum L-arginine at the 75th (84 μmol/L) versus 25th (46 μmol/L) percentile (95% CI: 5.99–13.62). L-arginine had the best discriminative ability with a bias-adjusted area under the receiver operator characteristic curve of 0.859. Conclusions: Higher serum concentrations of L-arginine and endogenous methylarginines are strongly associated with IBS in adults.]]> Wed 14 Dec 2022 09:23:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33716 Wed 12 Dec 2018 14:03:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16959 -7), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05–1.32); meta-analysis p = 2.6×10^-8). The nearby gene, MMP12, was significantly over expressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10^-15; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p<0.001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS.]]> Wed 11 Apr 2018 17:21:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14963 Wed 11 Apr 2018 17:03:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16807 -9), and IKZF1 rs1110701 (OR 1.69, CI 1.42–2.02, p = 7.26 x 10^-9). There was evidence of gene-environment interaction for risk genotype at IKZF1, whereby an apparently stronger genetic effect was observed if the mother took folic acid or if the father did not smoke prior to pregnancy (respective interaction P-values: 0.04, 0.05). There were no interactions of risk genotypes with age or sex (P-values >0.2). Our results evidence that interaction of genetic variants and environmental exposures may further alter risk of childhood ALL however, investigation in a larger population is required. If interaction of folic acid supplementation and IKZF1 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements.]]> Wed 11 Apr 2018 16:52:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22259 Wed 11 Apr 2018 16:19:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10560 Wed 11 Apr 2018 16:11:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14939 Wed 11 Apr 2018 15:21:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20024 Wed 11 Apr 2018 15:18:06 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13534 Wed 11 Apr 2018 14:07:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13531 Wed 11 Apr 2018 12:58:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16758 Wed 11 Apr 2018 12:47:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11800 3).]]> Wed 11 Apr 2018 11:11:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30590 Wed 11 Apr 2018 10:46:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15182 Wed 11 Apr 2018 10:23:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11796 Wed 11 Apr 2018 10:08:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17559 Wed 11 Apr 2018 09:42:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1820 =65 years of age. Case-fatality rates showed similar trends with a 1- to 2-month lag compared with attack rates. Conclusions: There is an increase in stroke attack rates and case-fatality rate from summer to winter in the Hunter Region, Australia. These trends are similar to those found in the Northern Hemisphere.]]> Wed 11 Apr 2018 09:35:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14826 Wed 11 Apr 2018 09:25:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13741 Wed 11 Apr 2018 09:24:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37857 Wed 10 Nov 2021 15:12:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32689 Wed 10 Nov 2021 15:04:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33341 Wed 09 Mar 2022 16:04:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34208 −8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.]]> Wed 04 Sep 2019 09:48:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55026  2 neurological features, demonstrated excellent discrimination: AUC of 0.953 (95% CI: 0.916, 0.987). A predictive scoring system (total score/7) identified an optimal threshold of ≥ 3 points, with a sensitivity of 87% and specificity of 79%. Conclusions: The study identified a diagnostic support tool with four variables to predict increased risk of CAD. Validation in a clinical sample is needed to confirm variables and refine descriptors to enable clinicians to efficiently apply the tool.Optimum cutoff scores of ≥ 3/7 points will help identify those in whom CAD should be considered and further investigation instigated. The potential impact of the tool is to improve early recognition of CAD in those with acute headache or neck pain, thereby facilitating more timely medical intervention, preventing inappropriate treatment, and improving patient outcomes.]]> Wed 03 Apr 2024 15:48:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42651 Wed 01 Mar 2023 15:00:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13827 Tue 24 Aug 2021 14:26:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42696 Tue 14 Nov 2023 14:44:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41379 Tue 04 Apr 2023 19:08:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41383 Tue 02 Aug 2022 15:48:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41188 75%) was observed for all the pooled analyses. Publication bias was also identified. Conclusion: There was no evidence for preferring one type of behaviour change intervention strategy, nor for including multiple strategies in improving thrombolysis rates. However, the study results should be interpreted with caution, as they display high heterogeneity and publication bias.]]> Thu 28 Jul 2022 11:05:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22920 Thu 27 Jan 2022 15:57:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35094 Thu 20 Jun 2019 15:56:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43342 Thu 15 Sep 2022 15:18:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34467 -1.min^-1) underwent a clinical evaluation of known risk factors by a physician and comprehensive laboratory analysis of immune responses both at rest and after two cycling ergometer tests: 60 min at 65% VO₂max (LONG); and 6 x 3 min intervals at 90% VO₂max (INTENSE). Blood tests were performed to determine Epstein Barr virus (EBV) status and DNA was genotyped for a panel of cytokine gene polymorphisms. Saliva was collected for measurement of IgA and detection of EBV DNA. Athletes were then followed for 9 months for self-reported episodes of respiratory illness, with confirmation of the underlying cause by a sports physician. There were no associations with risk of respiratory illness identified for any parameter assessed in the clinical evaluations. The laboratory parameters associated with an increased risk of respiratory illnesses in highly-trained athletes were cytokine gene polymorphisms for the high expression of IL-6 and IFN-γ expression of EBV-DNA in saliva; and low levels of salivary IgA concentration. A genetic risk score was developed for the cumulative number of minor alleles for the cytokines evaluated. Athletes prone to recurrent respiratory illness were more likely to have immune disturbances that allow viral reactivation, and a genetic predisposition to pro-inflammatory cytokine responses to intense exercise.]]> Thu 14 Mar 2019 16:50:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27007 Thu 13 Jan 2022 10:29:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36636 Thu 09 Dec 2021 11:03:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46986 Thu 06 Jul 2023 15:13:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29940 Thu 04 Nov 2021 10:39:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34747 Thu 02 May 2019 11:16:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13803 Sat 24 Mar 2018 10:41:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13802 Sat 24 Mar 2018 10:41:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13747 Sat 24 Mar 2018 10:39:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13303 Sat 24 Mar 2018 10:36:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31408 Sat 24 Mar 2018 08:45:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31219 Sat 24 Mar 2018 08:43:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1064 Sat 24 Mar 2018 08:32:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1119 Sat 24 Mar 2018 08:32:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14670 Sat 24 Mar 2018 08:19:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12412 Sat 24 Mar 2018 08:14:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10741 Sat 24 Mar 2018 08:14:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11344 Sat 24 Mar 2018 08:08:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18168 Sat 24 Mar 2018 08:04:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17373 Sat 24 Mar 2018 08:01:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21233 P < 5 × 10⁻⁸) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.]]> Sat 24 Mar 2018 07:53:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19175 Sat 24 Mar 2018 07:52:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21021 N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.]]> Sat 24 Mar 2018 07:50:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29272 Sat 24 Mar 2018 07:39:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28407 Sat 24 Mar 2018 07:36:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30288 Sat 24 Mar 2018 07:33:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28420 G-monomethyl-L-arginine (MMA), N^G,. N^G-dimethyl-L-arginine (ADMA) and N^G,. N^G'-dimethyl-L-arginine (SDMA), all of which have the capacity to alter NOS activity. Simultaneous assessment of these analytes, when assessing the impact of arginine metabolism in human disease states, is desirable. Methods: Analytes (ARG, ADMA, SDMA, MMA, HMA, CIT and ORN) were isolated from human plasma by solvent extraction, evaporated and reconstituted. Ultra-performance liquid chromatography (UPLC) was performed on a 150mm×2.1mm T3 HSS column using a gradient mobile phase comprising ammonium formate (10mM, pH3.8) in methanol (1% to 63%). Analytes were detected by time-of-flight mass spectrometry (Q-ToF-MS) in positive ion mode with electrospray ionisation (ESI+). Data were collected using MS^E. Results: Solvent extraction provided high recovery (>95%). UPLC-QToF-MS^E facilitated the separation and quantification of the 7 analytes in an analysis time of 6min. The approach has high sensitivity; LOQ range from 0.005µM (NMMA) to 0.25µM (ARG and ORN), and good precision; intra- and inter-day %RSD are <6% for all analytes. Conclusions: This approach provides the capacity to quantify 7 key compounds involved in ARG metabolism in a small sample volume, with a short total analysis time. These characteristics make this approach ideal for undertaking a comprehensive characterisation of this pathway in large data sets (e.g. population studies).]]> Sat 24 Mar 2018 07:29:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28443 Sat 24 Mar 2018 07:29:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25883 Sat 24 Mar 2018 07:25:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4616 Sat 24 Mar 2018 07:21:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4621 Sat 24 Mar 2018 07:21:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23033 Sat 24 Mar 2018 07:13:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50640 Mon 31 Jul 2023 16:34:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16768 Mon 26 Nov 2018 15:27:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32077 0.05). Global DNA methylation levels in males were significantly higher than in females (median %5-mC: 1.82 vs. 1.03, males and females respectively, (P < 0.05)). Conclusion: No association was found between the intake of one-carbon metabolism nutrients during the early postnatal period and global DNA methylation levels at age four years. Higher global DNA methylation levels in males warrants further investigation.]]> Mon 23 Sep 2019 11:18:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48940 Mon 17 Apr 2023 14:57:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46970 Mon 12 Dec 2022 16:19:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35821 Mon 09 Dec 2019 16:18:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55070 Mon 08 Apr 2024 13:27:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11187 Mon 08 Apr 2019 11:10:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33670 Mon 01 Jul 2019 09:50:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33959 Fri 25 Jan 2019 11:54:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34521 Fri 22 Mar 2019 12:59:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42290 Fri 19 Aug 2022 14:58:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47250 Fri 16 Dec 2022 12:29:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40011 p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)). Conclusion: No association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta-analyses.]]> Fri 15 Jul 2022 10:09:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49387 60 years old and accepted onto the National Organ Matching Service. This RKT Group was divided into donor renal cancers ≤30 mm and >30–≤50 mm. Adverse event profiles for RKT recipients were compared with 22 standard live donor recipients using logistic regression analyses. Recipient and transplant survivals for RKT were compared with 2050 controls from Australian New Zealand Dialysis Transplant Registry using Cox regression models. To increase statistical power for survival analyses, data from 25 RKT recipients from Princess Alexandra Hospital, Brisbane were added, thus creating 48 RKT recipients.Results: There were no significant differences in mortality, transplant failure nor AEs between the 2 cancer Groups. RKT increased the risks of Adverse event profiles (odds ratio: 6.48 [2.92–15.44]; P < 0.001). RKT reduced mortality risk by 30% (hazard ratio [HR]: 0.70 [0.36–1.07]; P = 0.299) compared with those continuing on the transplant list who may or may not be transplanted. RKT significantly reduced mortality risk for those remaining on dialysis (HR: 2.86 [1.43–5.72]; P = 0.003). Transplant survival for RKT was reduced compared with control deceased donor (HR: 0.42 [0.21–0.83]; P = 0.013) and live donor transplants (HR: 0.33 [0.02–0.86]; P =0.023).Conclusions:The use of larger carefully selected cancer-resected kidneys for transplantation appears safe and effective. RKT confers a possible survival advantage compared with waiting for transplantation, an increased survival compared with those remaining on dialysis but reduced transplant survival.]]> Fri 12 May 2023 14:27:13 AEST ]]>